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 Forum index » Archive » Archive: Perplex City » PXC: General/Updates
[UPDATE] Sentinel - 03 April 06 - Drug Trials
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duckiemonster
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Joined: 10 Dec 2005
Posts: 554
Location: Oxford, UK

/me has a Strongbad moment. It is soon over.


I don't think this new drug is all that different to the ones used in Earth medicine for Alzheimers, bi-polar disorder, epilepsy, psychotic illnesses and the like or the sedatives that we have.

Did Miranda give it to him? For some more idle spec, perhaps he took her into his confidence about the barrow-feld and thought that she was helping him. Perhaps not.
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PostPosted: Tue Apr 04, 2006 4:03 am
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European Chris
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Joined: 19 Jul 2005
Posts: 1264
Location: London's trendy Whitechapel

Re: [UPDATE] Sentinel - 03 April 06 - Drug Trials

oliverkeers13 wrote:
I think that this is utterly outrageous. Players grumbled last time that the packs were mixed, and Mind Candy said it was due to printers being difficult, and that they'd sort it. They knew this, and still released them mixed. People will have to pay more to complete their sets now. This means that there'll be a bigger ebay trade, and, from Mind Candy's point of view, more money. I really resent having to make a decision between spending more or waiting "several weeks" to be able to get my hands on the cards that I want. This shows that they were able to separate the waves, but chose not to, due to greed. I'm really not happy about this Evil or Very Mad


Don't worry Ollie, I'm sure you'll be near the top of the leaderboard soon. Have one of those Ritalins and play in the sand pit for half an hour to calm yourself down.

However the article would indicate a botched testing. All we can be confident with is that the drug came from a well funded and technically able source. Unless we know Miranda does have links to 'people' with these resources it's all a bit wild specy.
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PostPosted: Tue Apr 04, 2006 7:01 am
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cassandra
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Joined: 25 Mar 2005
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I'm not sure how the lethal drug can really be Veritana(-esque) when it clearly is ceretiva-derived on the autopsy report. Not saying Isaac couldn't have had Barrow-Feld (which would explain why Violet thought him slimy at times), but there should also be a chemical signature for versions of Veritana (which also should have completely different neural mechanisms/overdose symptoms than a stimulant).

The drug that worries me a bit is Neuroceptin (I'm assuming it's similar to Thorazine or another neuroleptic) - mostly the fact that you can obtain it for use on somebody else.
Quote:
Major Castille had given me, in amongst my supplies, a little bit of Neuroceptin - it's a prescription medication for people who are overly aggressive and violent. Given to normal people it makes them woozy, docile and biddable. Major Castille thought I might need it if I had to slip past a guard or evade capture. It's in a spray canister - just spray it on any exposed area of skin and it's absorbed within three seconds. So my plan, such as it was, was to go into Viendenbourg, just as I had done before, spray Allain with the Neuroceptin, and walk him out of the compound, maybe take him a couple of days journey from Viendenbourg, then call Major Castille. It didn't quite work out like that.


PostPosted: Tue Apr 04, 2006 11:46 am
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duckiemonster
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To be fair, any prescription drug can have side-effects that could potentially be used for evil. Even non-prescription drugs have potential for evil; it's possible to kill people with paracetamol... heck, you can make some people ill with cough sweets*

I don't think the suggestion is that it was the trial drug that knocked him off, but that he might have thought he was taking the trial drug, then someone slipped him something else that looks the same, but would be lethal at that dosage, or had cumulative effects over several weeks.

But all this spec kind of hinges on whether Cymballisty actually had barrow-feld or not.


*as long as your victim has PKA and the cough sweets have phenylalanine in them.
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PostPosted: Tue Apr 04, 2006 11:55 am
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cassandra
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Ah, I see now. Though the fact that it was dissolved in the coffee is still strange, if IC knew he was taking a drug..

Something else about Veritana I don't quite understand: the drug trials at Cognivia were initiated in late 266. From the article:
Quote:
Then, in late 266, Jannsen received a request for candidates to participate in an experimental drug trial at Cognivia for patients suffering from Barrow-Feld. Lowry-Barton was one of the first patients enrolled in the program, and Cognivia came forward to announce its first success with the new drug, Veritana.


Yet, today in 269, Harrowak was forced to step down, and the state of medical therapy was reported as:
Quote:
"In our modern day, we can monitor Barrow-Feld Syndrome and be sure that no harm is being done," she said. "Julian is in excellent health, and to date, absolutely no symptoms of the disease have manifested in his brain patterns. ... This is an act of gross ingratitude to a physician who has given so much of his life to the service of our city."

Vickering is the obvious first choice to step up to the post, but she has said that she may refuse to do so as an act of protest against the City Council's decision. She said that Cognivia has reported significant strides against the disease in drugs coming down its pipeline, and that a complete cure might even become available long before Harrowak manifests any symptoms whatsoever.


Sure, he might be younger than 40, but the two stories don't seem to match up. Why didn't they discuss Veritana in the Harrowak article, even as an experimental treatment? Lowry-Barton is not the only (partial) success they've had, or they wouldn't be able to know that the drug isn't as potent in the under-40 crowd. Or maybe I'm overthinking the phrasing. I wish the article were clear about *when* Lowry-Barton was announced as the first successful reversal.

PostPosted: Tue Apr 04, 2006 2:15 pm
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Scott
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I took it to mean she is only just now marked as being a success story. She has been undergoing treatment and observation fFor some while, and now, this week, doctors are confident in declaring her Cured. But I see how I could be wrong there.

By the way, I'm given to think Cymbalisty didnt have Barrow-Feld. He may be creepy, but that doesn't mean he had difficulty with ethical decision-making. As fFar as we know, he wasn't lying, cheating, or stealing. I'd suppose we don't have any solid evidence here yay or nay. But Anna seemed to think he was a good and fFair man. Not at all the sort prone to inconsistent moral choices. But then, maybe he was really good at controlling it. Perhaps we should simply ask Anna, eh.
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PostPosted: Tue Apr 04, 2006 3:13 pm
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zaeil
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Joined: 31 Aug 2004
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The stories match up fine. First of all, Lowry-Barton's Barrow-Feld is not reversed. The article states that she still feels anti-social impulses but the Veritana makes it possible for her to ignore them--for her to act as herself and not as a prisoner of the disease. And the drug is still in clinical trials, probably only Phase I or II based on the timeframe.

As for Harrowak, he might not have wanted to take part in the clinical trial, or might not have even known about it. Also, a pharmaceutical company generally doesn't publicize drugs it has in trials unless subjects are needed (and even then, the publicity tends to be kept low-key), so the media likely didn't know about it to report it until now.

I have to throw in here that I don't think that Cymbalisty was taking Veritana in his coffee! It'd be a unusual delivery method to say the least, and most likely outside the guidelines for the clinical trial. That is, presuming he was part of it, which I don't think he was. I'm more inclined to think that he was a casual user of Ceretin. Maybe he didn't think he was all that bright compared to his peers--and in a society where intelligence is highly prized, having such a view of himself might drive him to artificially enhance that aspect. Still can't really explain the possible black-market Ceretiva derivative, though!
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PostPosted: Tue Apr 04, 2006 3:24 pm
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